When will this shit end?

[stuartbert two hats]

A DNA vaccine. What does our professor think? @Toilet Duck

 

 

[Guest]

1 hour ago, stuartbert two hats said:

I know the link between cases and deaths has been if not broken, then at least drastically changed - but this isn't nice to see.

The pattern with these rises has tended to subside after a few days, then head back down again. Even with the occasional weekly rise, it's almost always been down over 10-14 days.

This is not happening with Bolton at the moment. It's been a long time (3rd April) since cases were this high there. I wonder if the government will consider ramping up vaccination efforts in Bolton to aid with containment?

 

I wonder why Bolton are seeing cases rise as they are, has there been any reasons given yet?

[Ryan1984]

Do we get a more formal decision about the next stage of the roadmap this week?

One of them will say something in the Commons, won’t they?

[Guest]

5 minutes ago, Ryan1984 said:

Do we get a more formal decision about the next stage of the roadmap this week?

One of them will say something in the Commons, won’t they?

Yeah, we get confirmation that we can proceed with the next stage of the roadmap a week before it is due to come into effect. They’ll probably have a press briefing and announce in the Commons if MPs are sitting after prorogation. 

[stuartbert two hats]

10 minutes ago, Ozanne said:

I wonder why Bolton are seeing cases rise as they are, has there been any reasons given yet?

The MEN story a few days ago mentioned the Indian variant, but I couldn't work out whether that was conjecture or not. It wouldn't surprise me if that was the case.

[Guest]

1 minute ago, stuartbert two hats said:

The MEN story a few days ago mentioned the Indian variant, but I couldn't work out whether that was conjecture or not. It wouldn't surprise me if that was the case.

Yes I remember that now, cheers. Has vaccine uptake been an issue?

[stuartbert two hats]

6 minutes ago, Ozanne said:

Yes I remember that now, cheers. Has vaccine uptake been an issue?

I'm really not sure. Not as far as I'm aware, but I may have missed it. 

[swede]

1 hour ago, steviewevie said:

I'm not hugging anyone. They can't make me.

Shit !! I hugged my mother in law today, it’s her birthday, lock us up and throw away the keys ! 

[faymondo]

2nd vaccine today let me into the nightclubs.

Well OK maybe not I am 47 but a gig would be nice.

[Toilet Duck]

1 hour ago, stuartbert two hats said:

A DNA vaccine. What does our professor think? @Toilet Duck

 

 

So, the benefit of DNA over RNA is generally stability as well as sustained expression. As it happens, the OX/AZ, J&J, Sputnik and all the other adenoviral vaccines are also DNA vaccines (they just use the attenuated adenovirus to get the DNA into our cells (in the case of this one, it’s short electrical pulses to permeabilise our cells that enhances uptake)). The mRNA vaccines in the nanoparticles work really well. Free DNA from the adenoviral vaccines is postulated to be the trigger for the immune-mediated thrombocytopenia observed with the adenoviral vaccines, so may have the same issue here. While stability was previously an issue with RNA, the formulations being used now last long enough to make the spike in our cells for about 6 days, which is plenty and the labile nature of RNA is quite handy in a vaccine as it aids clearance. These guys have a novel approach, it’s another genetic vaccine, so easy to update, though it needs a specialised device following injection to promote uptake of the vaccine, which to me would limit its use somewhat. But...the more the merrier!

[Suprefan]

 

[steviewevie]

6 hours ago, Suprefan said:

 

https://www.theguardian.com/world/2021/may/08/us-coronavirus-vaccine-demand-states-turning-down-doses

[Guest]

6 hours ago, Suprefan said:

 

What does that even mean!?

[Guest]

Wrong thread. 

Edited May 9, 2021 by Ozanne

[Avalon_Fields]

10 hours ago, Ozanne said:

Yes I remember that now, cheers. Has vaccine uptake been an issue?

To my knowledge it's not too bad in the Pakistani/Indian communities, the BMJ has a stat of 74%, and I don't know of a reason why it would be much different from that in nearby Bolton. It's the African and Caribbean communities that have the lowest uptake (Mainly N & Central Manchester, not so much Bolton).

There's definitely more refusal of the AZ vaccine in all these groups compared to whites (In my experience) which is a challenge as there is a concerted effort to reach out to these communities by mobile vaccination sites, in the likes of supermarket car parks close to specific communities, which is inevitably AZ hence may be an issue.

 

[efcfanwirral]

18 minutes ago, Avalon_Fields said:

To my knowledge it's not too bad in the Pakistani/Indian communities, the BMJ has a stat of 74%, and I don't know of a reason why it would be much different from that in nearby Bolton. It's the African and Caribbean communities that have the lowest uptake (Mainly N & Central Manchester, not so much Bolton).

There's definitely more refusal of the AZ vaccine in all these groups compared to whites (In my experience) which is a challenge as there is a concerted effort to reach out to these communities by mobile vaccination sites, in the likes of supermarket car parks close to specific communities, which is inevitably AZ hence may be an issue.

 

What was the issue last summer that was making it spread?   There, Oldham, Rochdale etc were always the worst and it can't just be shops because it would surely be rising everywhere if so. There can be less vaccine uptake as one piece of the puzzle but Bolton was always an outlier in terms of spreading when everywhere else wasn't when the vaccine wasn't a factor, so feels like there's more to it 

Edited May 9, 2021 by efcfanwirral

[Guest]

1 hour ago, Avalon_Fields said:

To my knowledge it's not too bad in the Pakistani/Indian communities, the BMJ has a stat of 74%, and I don't know of a reason why it would be much different from that in nearby Bolton. It's the African and Caribbean communities that have the lowest uptake (Mainly N & Central Manchester, not so much Bolton).

There's definitely more refusal of the AZ vaccine in all these groups compared to whites (In my experience) which is a challenge as there is a concerted effort to reach out to these communities by mobile vaccination sites, in the likes of supermarket car parks close to specific communities, which is inevitably AZ hence may be an issue.

 

Thanks, that’s really interesting. The AZ point might be a big part of it now you mention it.

[shoptildrop]

13 hours ago, stuartbert two hats said:

The MEN story a few days ago mentioned the Indian variant, but I couldn't work out whether that was conjecture or not. It wouldn't surprise me if that was the case.

I'm sure I've read somewhere the rise in cases there is in the younger folks who haven't been vaccinated yet... 

But we also know there is a lower take up by the Asian communities in the north areas of Manchester, so if Indian variant is about then it's potentially spreading in the unvaccinated but I don't know for sure

[shoptildrop]

4 hours ago, Ozanne said:

What does that even mean!?

I'm thinking the same thing.... like what are they suggesting there?

[shoptildrop]

In other news received text last night from GP for my 2nd jab which will be on Friday, so 11 weeks after 1st one

So I'm happy with that news 😁

[Guest]

42 minutes ago, shoptildrop said:

I'm thinking the same thing.... like what are they suggesting there?

I really have no idea, it’s probably not even worth looking it up 😆

[Crazyfool01]

44 minutes ago, shoptildrop said:

In other news received text last night from GP for my 2nd jab which will be on Friday, so 11 weeks after 1st one

So I'm happy with that news 😁

friday second jab crew too 🙂 

[Guest]

Congrats guys. My Mum had her second jab on Thursday as well!

[philipsteak]

Just got back from getting my second jab. Nice to get it in before the hostel reopens and the hordes return

[BobWillis2]

 

That’s social distancing in the bin. Masks next.