When will this shit end?

[squirrelarmy]

Any more on the rumours of more area’s going into tier 4?

[zahidf]

1 minute ago, squirrelarmy said:

Any more on the rumours of more area’s going into tier 4?

Tbh I'm expecting the whole country in tier 4 for Jan

[Guest]

5 minutes ago, squirrelarmy said:

Any more on the rumours of more area’s going into tier 4?

Vallance indicated that many areas will be heading into tier 4 after Christmas. 

[stuartbert two hats]

3 minutes ago, zahidf said:

Tbh I'm expecting the whole country in tier 4 for Jan

I'm thinking some time between boxing day and new year. Shut the shops.  And wouldn't be surprised if the kids stay back an extra couple of weeks.

[Ted Dansons Wig]

Drive my car into the ocean. You think I’m dead but I sail away...

[stuartbert two hats]

Anyway, what's next on the vaccine front? Does anyone know of a site that gives a good rundown on our preorders?

 

Specifically, are there any vaccines we might get before the Moderna one? If there is supply and we're not at the back of the queue I'm hoping there might be another one we can get going with in January or February?

[Mr.Tease]

19 minutes ago, steviewevie said:

 

'over-promising' Why do they still avoid calling it what it is: lying? 

[steviewevie]

 

[steviewevie]

So, we're going to call it Tier4 instead of lockdown?

[mazola]

4 hours ago, fatyeti24 said:

 

Making the most of tier 2 while it lasts. 

'When I were a lad, a pub snack was gravel and a wooden spoon, and bloody happy with it we were too!'

[steviewevie]

 

[Zoo Music Girl]

49 minutes ago, fatyeti24 said:

Being a long time admirer of Kunt (nee Kunt and the Gang - check out his older stuff on Youtube), I have to admit I'm finding his latter day success incredibly amusing.

Come on Kunt!

 

33 minutes ago, philipsteak said:

Think I first became aware of him with Use my Arsehole as a c**t, which apparently got to number 66!

I've seen him a few times back in the day, gloriously puerile stuff. New one is catchy! 

[incident]

5 minutes ago, stuartbert two hats said:

Anyway, what's next on the vaccine front? Does anyone know of a site that gives a good rundown on our preorders?

 

Specifically, are there any vaccines we might get before the Moderna one? If there is supply and we're not at the back of the queue I'm hoping there might be another one we can get going with in January or February?

The 1 dose regiment of Janssen (30 million ordered) is expected to report in January and potentially file for approval in February.

Novavax (60 million ordered) should be about 3-4 weeks behind them.

A month or so back, Janssen did start a second trial on a 2-dose regiment which should report around Easter.

While I don't know delivery timescales, or manufacturing capacity, we should be near the front of the queue for both, especially Novavax which I think we were the first to order and has UK manufacturing capability.

Beyond that, there's nothing worth talking about - the other orders we have are for Valneva which is still in early stages and GSK/Sanofi which has gone back to the drawing board after their Phase 1 trial didn't get the results they hoped for.

[Toilet Duck]

16 minutes ago, stuartbert two hats said:

Anyway, what's next on the vaccine front? Does anyone know of a site that gives a good rundown on our preorders?

 

Specifically, are there any vaccines we might get before the Moderna one? If there is supply and we're not at the back of the queue I'm hoping there might be another one we can get going with in January or February?

J&J expect to unblind towards the end of January (for the one shot regimen, 2 shot regimen still enrolling participants)...Novavax expect to unblind towards the end of March...that probably gives J&J a chance of approval before the Moderna shots are available in the UK (April maybe? Depends on how Lonza get on making them in Switzerland really)...Oxford of course would make the biggest difference. Who knows, the Russian or Chinese ones could try submitting data to the MHRA! (Though the UK doesn’t have any orders for those, but the interim phase 3 data is there for the Russian vaccine)...

 

edit: @incident beat me to it!

Edited December 21, 2020 by Toilet Duck

[efcfanwirral]

4 minutes ago, steviewevie said:

 

Sleepwalking into MORE disaster

[squirrelarmy]

Lock the south down now! 

[stuartbert two hats]

6 minutes ago, incident said:

The 1 dose regiment of Janssen (30 million ordered) is expected to report in January and potentially file for approval in February.

Novavax (60 million ordered) should be about 3-4 weeks behind them.

A month or so back, Janssen did start a second trial on a 2-dose regiment which should report around Easter.

While I don't know delivery timescales, or manufacturing capacity, we should be near the front of the queue for both, especially Novavax which I think we were the first to order and has UK manufacturing capability.

Beyond that, there's nothing worth talking about - the other orders we have are for Valneva which is still in early stages and GSK/Sanofi which has gone back to the drawing board after their Phase 1 trial didn't get the results they hoped for.

 

5 minutes ago, Toilet Duck said:

J&J expect to unblind towards the end of January (for the one shot regimen, 2 shot regimen still enrolling participants)...Novavax expect to unblind towards the end of March...that probably gives J&J a chance of approval before the Moderna shots are available in the UK (April maybe? Depends on how Lonza get on making them in Switzerland really)...Oxford of course would make the biggest difference. Who knows, the Russian or Chinese ones could try submitting data to the MHRA! (Though the UK doesn’t have any orders for those, but the interim phase 3 data is there for the Russian vaccine)...

 

edit: @incident beat me to it!

Thanks both, exactly the kind of info I was looking for 🙂

[stuartbert two hats]

3 minutes ago, squirrelarmy said:

Lock the south down now! 

Ban scotch eggs!

[steviewevie]

3 minutes ago, squirrelarmy said:

Lock the south down now! 

need to lock the whole country down really. 

[zahidf]

Basically waiting/hoping for oxford to get approved. 

[Crazyfool01]

1 minute ago, stuartbert two hats said:

Ban scotch eggs!

Eggspodential growth 

[Gingerfish79]

5 minutes ago, squirrelarmy said:

Lock the south down now! 

Build a wall 🤣

[Guest]

2 minutes ago, steviewevie said:

need to lock the whole country down really. 

They need to do something, I fear if they wait for this time next week (when Christmas is over) it might be too late.

[Toilet Duck]

Just now, stuartbert two hats said:

 

Thanks both, exactly the kind of info I was looking for 🙂

To be honest, Russia kind of shot themselves in the foot by jumping the gun with emergency use authorisation in Russia after only 78 participants...it made the scientific community skeptical. But, there’s actually some important things about that one. First, it’s an adenoviral vaccine like the Oxford one, but a human version (two different ones for each shot to avoid immune destruction of the second shot). The immune response wasn’t off the charts in their first paper, but their phase 3 interim data is as good as the Oxford data, and it gave 100% protection from severe disease (20 v 0). Safety profile looks the same too...but, they also gave a freeze dried version and it looks almost as good, making shipping a whole lot easier. Maybe their collaboration with Oxford will regain some trust.

[stuartbert two hats]

3 minutes ago, Toilet Duck said:

To be honest, Russia kind of shot themselves in the foot by jumping the gun with emergency use authorisation in Russia after only 78 participants...it made the scientific community skeptical. But, there’s actually some important things about that one. First, it’s an adenoviral vaccine like the Oxford one, but a human version (two different ones for each shot to avoid immune destruction of the second shot). The immune response wasn’t off the charts in their first paper, but their phase 3 interim data is as good as the Oxford data, and it gave 100% protection from severe disease (20 v 0). Safety profile looks the same too...but, they also gave a freeze dried version and it looks almost as good, making shipping a whole lot easier. Maybe their collaboration with Oxford will regain some trust.

It's clever that they seemed to have preempted the Achilles heel of the Oxford vaccine. Was it something that the Oxford lot had considered? Or did they think they were pretty likely to be safe because they used a chimp virus?