When will this shit end?

[steviewevie]

I always knew Blair would save us in the end.

[Supernintendo Chalmers]

1 hour ago, steviewevie said:

2036?

That's a fallow year...

[SwedgeAntilles]

3 minutes ago, steviewevie said:

I always knew Blair would save us in the end.

[Guest]

8 minutes ago, steviewevie said:

I always knew Blair would save us in the end.

He’s the hero we need right now. 

[Crazyfool01]

1 minute ago, Ozanne said:

He’s the hero we need right now. 

So he’s not a weapon of mass destruction anymore ? 

[SwedgeAntilles]

He's certainly still a weapon. 

[steviewevie]

15 minutes ago, crazyfool1 said:

So he’s not a weapon of mass destruction anymore ? 

he's the centrist dad we all need right now.

[Chawk]

2 hours ago, parsonjack said:

I vote this thread ends with the last post being a group photo at the next meet on the farm.  

with the state of this thread a fight would break out

Edited December 27, 2020 by Chawk

[DeanoL]

2 hours ago, zahidf said:

People will start household mixing once deaths and hospitalisations are down. So other restrictions are pointless IMO

There is a way to allow household mixing but keep it controlled - it’s basically what they were initially proposing at Christmas - let people have exclusive bubbles of say 12 people or three households or something like that.

[Mr.Tease]

33 minutes ago, zahidf said:

FT news on Oxford vaccine. Approval due on Tuesday and they are considering Tony Blair plan

 

If the research has been based on 2 doses, and also half a dose followed by a full dose 28 days later, it's just daft to throw that out the window and just do 1 dose

[zahidf]

6 minutes ago, DeanoL said:

There is a way to allow household mixing but keep it controlled - it’s basically what they were initially proposing at Christmas - let people have exclusive bubbles of say 12 people or three households or something like that.

But people won't even follow that once deaths and hosptialisations are down.

[Lycra]

44 minutes ago, zahidf said:

FT news on Oxford vaccine. Approval due on Tuesday and they are considering Tony Blair plan

 

The MHRA follow evidence based medicine, not the suggestions of washed up politicians.

[zahidf]

Just now, Lycra said:

The MHRA follow evidence based medicine, not the suggestions of washed up politicians.

Well then there is some evidence base to them looking at the one dose suggestion. FT is reliable with these things 

[stuartbert two hats]

16 minutes ago, Mr.Tease said:

If the research has been based on 2 doses, and also half a dose followed by a full dose 28 days later, it's just daft to throw that out the window and just do 1 dose

What if it's not? The Pfizer data strongly suggests immunity kicks in on one dose, even if it doesn't have anything to say about maintaining it.

 

 

[Lycra]

Just now, zahidf said:

Well then there is some evidence base to them looking at the one dose suggestion. FT is reliable with these things 

None has been published. The MHRA work on statistically sound evidence based medicine. That's why phase 3 trials involve 10,000s of people.  

[Lycra]

3 minutes ago, stuartbert two hats said:

What if it's not? The Pfizer data strongly suggests immunity kicks in on one dose, even if it doesn't have anything to say about maintaining it.

 

 

The PM vaccine is radically different to the AZ and it would be unwise to make a comparison. Undoubtedly some degree of immunity kicks in after dose 1 but it's not been quantified to a proper scientific conclusion.

If we consider PB v AZ, the former is a purer solution as the mRMA codes only for the virus protein spike whereas the AZ adenovirus contains the protein spike gene amongst many others. It like using a pure chemical compared to a dilute solution.

 

Edited December 27, 2020 by Lycra

[zahidf]

3 minutes ago, Lycra said:

None has been published. The MHRA work on statistically sound evidence based medicine. That's why phase 3 trials involve 10,000s of people.  

Let's see what's happens on Tuesday. There has been more evidence submitted to the MHRA. I didn't think it likely with one dose at first, but the FT is a reliable source, so there must be something they are looking at 

[Lycra]

4 minutes ago, zahidf said:

Let's see what's happens on Tuesday. There has been more evidence submitted to the MHRA. I didn't think it likely with one dose at first, but the FT is a reliable source, so there must be something they are looking at 

Personally I think we've had a lot of political spin put out by government over the last 24hrs to get us all feeling good.

[zahidf]

2 minutes ago, Lycra said:

Personally I think we've had a lot of political spin put out by government over the last 24hrs to get us all feeling good.

That's not a bad thing when it comes to vaccines. Too doom laden and people will just give up. Some hope and people will follow more to give time for vaccinations.

Anyway, FT says its MHRA source rather than a govt one 

[steviewevie]

4 minutes ago, Lycra said:

Personally I think we've had a lot of political spin put out by government over the last 24hrs to get us all feeling good.

not working with me, just feeling the usual post xmas blurgh.

[Crazyfool01]

We will find out very soon I guess .... although im disappointed it doesnt fit with the Monday announcement schedule #thereisnopattern 

[incident]

14 minutes ago, stuartbert two hats said:

What if it's not? The Pfizer data strongly suggests immunity kicks in on one dose, even if it doesn't have anything to say about maintaining it.

 

 

Pfizer is an entirely different type of vaccine - but more importantly, that Pfizer data doesn't provide any indication as to what happens after X (in their case 21, in the case of Oxford 28) days without the second dose - the protection might fade away. I don't think that's being alarmist - that's literally one of the reasons many other vaccines are delivered as 2 dose shots.

It's worth remembering that Oxford originally started one of their early trials as a one-dose regiment, then converted it to a two dose when the data came in so clearly they believe there's a substantial a benefit to the second dose. Plus if the the new data still suggests a 1.5 dose regiment is the most effective option, then relying on that first half dose would be a non starter.

As pointed out - the only way the MHRA/JCVI can or would approve the one dose idea is if they've got enough solid evidence - so far what we've seen doesn't come anywhere even close to that. Ultimately we've just got to see what new data is released - but if it does look like that Pfizer data, that shouldn't be anywhere near enough to approve a 1 dose regiment.

[steviewevie]

Covid-19: London Ambulance Service receives as many 999 calls as first wave

https://www.bbc.co.uk/news/uk-england-london-55461390

[Crazyfool01]

2 minutes ago, steviewevie said:

Covid-19: London Ambulance Service receives as many 999 calls as first wave

https://www.bbc.co.uk/news/uk-england-london-55461390

lets hope for Tier 4 to start making some impact very soon .... 

[ace56blaa]

So my housemate went to his parents ( in same town ) for Xmas and now his stepdad has tested positive. 

It's pretty obvious to me how all this was gonna play out. Just sucks cause I spent Xmas alone to minimize risk n it doesn't even matter. 

Stay safe out there!