TBH can't see many changes in comparison to 2020 lineup.
Most of announced headliners can be moved to 2022 (and probably will be due to contracts) - Dua Lipa, Calvin Harris, Kings of Leon. The only question is about The Strokes, but I hope in the end they'll be able to make it. IMO, Major Lazer should be downgraded to sub, and if so we have only two headline slots left - one for the "biggest artist" and another one.
Hope there will be more joint headliners, as The National / Macklemore or Foo Fighters / twenty on pilots!