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When will this shit end?


Chrisp1986

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2 minutes ago, ChemicalBrother said:

Boris uses an analogy of some 1800’s bugle player 

JVT uses a football analogy

One of the above is more in touch with the general public 

I’m not convinced the PM talking about “tooting” horns fills people with confidence 

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4 hours ago, Toilet Duck said:

Howdy folks...sorry I'm late to the party! Was in a meeting and could see notifications coming up!

So, looks very promising indeed. The vaccinated group not only didn't develop severe disease, but also had way fewer infections. Based on this, the suggestion is that the vaccine provides sterilising immunity (how long it lasts? far too early to say). By the numbers (94) it looks like Pfizer skipped their first planned interim analysis at 32 events and held on to get stronger data before unblinding. Appears that has paid off. They still need to wait until November 21st to get their follow up safety data before the FDA will grant EUA, but on the current efficacy data, that's a lock (unless people start keeling over). There's other good news too. The Moderna vaccine is right behind it, using exactly the same technology. Both are a pain in the arse to ship but much easier to scale up than previous vaccine platforms (and also much easier to adapt if the mink variant actually turns out to be a thing, you just insert the new sequence). Having two available would ramp up delivery as well. No indication so far either that the Oxford vaccine won't make it over the line as well, so best case scenario is a hat trick with the front runners with a whole posse of others brining up the rear later next year (J&J could even get there by the end of this year...that one did have sterilising immunity in pre-clinical studies, and Moderna claim theirs did too). The one major note of caution at this stage is that a sub-group analysis would be impossible at this stage, so how well the vaccine performs in high risk groups won't be known til the trials fully play out (not just older individuals, but different ethnic groups, people with different underlying co-morbidities etc). Also, none of the individuals that actually contracted the virus in the control group (or the vaccinated group) developed severe disease, so one of the primary endpoints of the trial can't be evaluated yet...however, if it provides 90% sterilising immunity, then that's a big (and fairly unexpected) win!

 

Edit: I should note, that all this is press releases. I haven't seen the actual data (hasn't been released), it will eventually be published and we can look at it in detail, but that process takes a lot longer than what occurred this morning!

Thankyou!

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This is good news, as expected, and is on the timeline that we have hoped for for some time.

Still not convinced that 2021 festival season is now on - still a way to go. Going to be a year or so before we are 'properly' back to what we recognise as normal.

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1 minute ago, Copperface said:

This is good news, as expected, and is on the timeline that we have hoped for for some time.

Still not convinced that 2021 festival season is now on - still a way to go. Going to be a year or so before we are 'properly' back to what we recognise as normal.

talk of spring from some ...

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12 minutes ago, March Hare said:

Reading between the lines, JVT saying, if enough old people are vaccinated, we can all to go Glasto ‘21. But didn’t say how many is enough. 

Reading between the lines with what he said about hospitalisation in over 50s you'd imagine when they're done, but it's all about whether there are enough vaccines to do it quickly enough? Or at least the knowledge it can be done by that time 

Boris is looking and sounding more relaxed than I've seen him in a long time, and even being polite to journalists!

Edited by efcfanwirral
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