When will this shit end?

[steviewevie]

Looks like readmitting Corbyn has not worked out too well for Starmer.  He is now disliked by both Corbynites and Jewish Labour..

[Euphoricape]

9 minutes ago, danmarks said:

Where abouts in the country are you? If its Bristol way i reckon you could be very much off for the day. Hope it goes however is best for you .

I'm in mid Cornwall so unlikely to be under highest restrictions unless its on a National level.

[Crazyfool01]

Just now, Euphoricape said:

I'm in mid Cornwall so unlikely to be under highest restrictions unless its on a National level.

What’s your rates now ? Hasn’t Cornwall had some recent outbreaks ? 

[JoeyT]

13 minutes ago, crazyfool1 said:

Looks like the south might be the new north when we get to Dec  

I think by the weekend we will see the South West begin to plateau with a decrease beginning next week.

[Euphoricape]

1 minute ago, crazyfool1 said:

What’s your rates now ? Hasn’t Cornwall had some recent outbreaks ? 

Its definitely the highest its been down here, there's been quite a few cases in my kids school and I know several people who are isolating with symptoms. The R rate is much higher down here for some reason, 1.2 to 1.4 currently.

[Crazyfool01]

1 minute ago, JoeyT said:

I think by the weekend we will see the South West begin to plateau with a decrease beginning next week.

Fingers crossed 🤞 

[Toilet Duck]

Had a read of the paper referenced above...excellent study! (I think one of the most in depth looks at the immune response to an acute viral infection ever published...ok, it’s not published yet, but it will be)...anyway, loads of interesting things in there.
 

Essentially, the antibody response is pretty variable and not a reliable indicator of immunological memory, so seroprevalence studies may not tell us how susceptible we are to reinfection. Even though they were variable though, they were pretty durable out to 6 months (they do decline, but in many individuals, not below a level that would be protective). 

T-cells that kill the virus were also still there at 6 months, they decline too, but they don’t have data for long enough to see if there is a bunch of them that hang around for a long time (they do for other CoV infections)...they also looked at another type of T cell (the ones that help our b-cells make antibodies). They too declined, but we’re still there after 6 months (they suspect they decline quickly at first and then plateau, keeping some of them around long term).

Finally they looked at b-cells (the part of our immune system that makes antibodies)...not only were they still there after 6 months, they actually increased, suggesting that ramping up a new antibody response upon re-exposure would be possible. The authors suggest that this should be long term immunological memory, maybe even like the 90 year b-cell memory seen for flu. Switching back on this response takes 3-5 days after exposure and given the clinical course of COVID, this would be sufficient to limit any reinfection to the upper respiratory tract (ie mild disease, maybe even just like a CoV-related common cold). 

The spike was still the dominant target  (they looked at other things that our immune systems target on the virus too), suggesting that vaccine-derived immunity should give similar responses. No indication that sterilising immunity is possible long term (so I suspect this virus is here to stay, though in purely evolutionary terms, this is a good thing as there no real reason for the virus to change), but basically, all still pointing in the direction of us being able to move this towards a mild and manageable infection (there will probably still be some serious cases, but they will be the exception rather than the rule)...

[zahidf]

6 minutes ago, Toilet Duck said:

Had a read of the paper referenced above...excellent study! (I think one of the most in depth looks at the immune response to an acute viral infection ever published...ok, it’s not published yet, but it will be)...anyway, loads of interesting things in there.
 

Essentially, the antibody response is pretty variable and not a reliable indicator of immunological memory, so seroprevalence studies may not tell us how susceptible we are to reinfection. Even though they were variable though, they were pretty durable out to 6 months (they do decline, but in many individuals, not below a level that would be protective). 

T-cells that kill the virus were also still there at 6 months, they decline too, but they don’t have data for long enough to see if there is a bunch of them that hang around for a long time (they do for other CoV infections)...they also looked at another type of T cell (the ones that help our b-cells make antibodies). They too declined, but we’re still there after 6 months (they suspect they decline quickly at first and then plateau, keeping some of them around long term).

Finally they looked at b-cells (the part of our immune system that makes antibodies)...not only were they still there after 6 months, they actually increased, suggesting that ramping up a new antibody response upon re-exposure would be possible. The authors suggest that this should be long term immunological memory, maybe even like the 90 year b-cell memory seen for flu. Switching back on this response takes 3-5 days after exposure and given the clinical course of COVID, this would be sufficient to limit any reinfection to the upper respiratory tract (ie mild disease, maybe even just like a CoV-related common cold). 

The spike was still the dominant target  (they looked at other things that our immune systems target on the virus too), suggesting that vaccine-derived immunity should give similar responses. No indication that sterilising immunity is possible long term (so I suspect this virus is here to stay, though in purely evolutionary terms, this is a good thing as there no real reason for the virus to change), but basically, all still pointing in the direction of us being able to move this towards a mild and manageable infection (there will probably still be some serious cases, but they will be the exception rather than the rule)...

Thanks for that! So positive news overall I guess

[Toilet Duck]

2 minutes ago, zahidf said:

Thanks for that! So positive news overall I guess

Yeah, pretty much!

[Punksnotdead]

55 minutes ago, crazyfool1 said:

Looks like the south might be the new north when we get to Dec  

My mum has had an operation cancelled next week because of increasing cases in my area of the south west (Cheltenham). 

[Ayrshire Chris]

43 minutes ago, Toilet Duck said:

Had a read of the paper referenced above...excellent study! (I think one of the most in depth looks at the immune response to an acute viral infection ever published...ok, it’s not published yet, but it will be)...anyway, loads of interesting things in there.
 

Essentially, the antibody response is pretty variable and not a reliable indicator of immunological memory, so seroprevalence studies may not tell us how susceptible we are to reinfection. Even though they were variable though, they were pretty durable out to 6 months (they do decline, but in many individuals, not below a level that would be protective). 

T-cells that kill the virus were also still there at 6 months, they decline too, but they don’t have data for long enough to see if there is a bunch of them that hang around for a long time (they do for other CoV infections)...they also looked at another type of T cell (the ones that help our b-cells make antibodies). They too declined, but we’re still there after 6 months (they suspect they decline quickly at first and then plateau, keeping some of them around long term).

Finally they looked at b-cells (the part of our immune system that makes antibodies)...not only were they still there after 6 months, they actually increased, suggesting that ramping up a new antibody response upon re-exposure would be possible. The authors suggest that this should be long term immunological memory, maybe even like the 90 year b-cell memory seen for flu. Switching back on this response takes 3-5 days after exposure and given the clinical course of COVID, this would be sufficient to limit any reinfection to the upper respiratory tract (ie mild disease, maybe even just like a CoV-related common cold). 

The spike was still the dominant target  (they looked at other things that our immune systems target on the virus too), suggesting that vaccine-derived immunity should give similar responses. No indication that sterilising immunity is possible long term (so I suspect this virus is here to stay, though in purely evolutionary terms, this is a good thing as there no real reason for the virus to change), but basically, all still pointing in the direction of us being able to move this towards a mild and manageable infection (there will probably still be some serious cases, but they will be the exception rather than the rule)...

Excellent,  well explained and easy to understand. Reckon even Father Dougal would understand that! 

[dotdash79]

Watching CNN and they are saying that the Pfizer CEO has passed its safety review and they are applying for emergency use. 

[dotdash79]

 

[steviewevie]

1 hour ago, crazyfool1 said:

Looks like the south might be the new north when we get to Dec  

cold and shit?

[steviewevie]

[steviewevie]

Manchester will be in Tier1 when come out of lockdown at this rate.

[zahidf]

[stuartbert two hats]

2 minutes ago, steviewevie said:

Manchester will be in Tier1 when come out of lockdown at this rate.

No such luck.  Stockport's numbers seem to have stalled.

17th- 334
16th- 339
15th- 337
14th- 327
13th- 336
12th-362
11th-362
10th-360

So sure, there's a week on week decrease, but it's not really been plummeting for a while now.  Good to see the likes of Wigan and Oldham finally see some decent drops, even Rochdale is seeing some sustained movement at last.

In all seriousness, I'm hopeful that Stockport at least will dip below the national average by the end of lockdown, but we'll have to see a resumption in the decline to hit that.

 

[Sawdusty surfer]

10 hours ago, eFestivals said:

the electorate are what they are. Failing to accept that is choosing to lose.  

Despite his many faults - and all leaders have many faults - was Blair much better than the current shithousery, or not? 

Hey in '97 things could have been much, much worse.

I, and a huge number of friends and aquaintences stood for parliament in the general election for the Rainbow Dream Ticket Party. My constituency was Totnes. 

Had a right laugh but thankfully got nowhere. We all would have been complete rubbish had we been elected.

[Lycra]

Deliberately being vague.....Sad to announce the death of a young nurse and mother of Covid-19 😢

Their dedication to work needs to be remembered.

Edited November 17, 2020 by Lycra

[Fuzzy Afro]

https://www.thesun.co.uk/news/13226133/christmas-five-day-festive-plan/
 

@DeanoLsounds like they’re found with your plan 

[Ozanne]

1 minute ago, Lycra said:

Deliberately being vague.....Sad to announce the death of a young nurse and mother of Covid-19 😢

Sorry to hear that, I hope you are ok as you can be. We are here if you need any of us. 

[parsonjack]

2 minutes ago, Lycra said:

Deliberately being vague.....Sad to announce the death of a young nurse and mother of Covid-19 😢

I'm so sorry.  To lose your life while saving lives of others is the cruelest blow.

Take care.

[ticketboy69]

5 minutes ago, Lycra said:

Deliberately being vague.....Sad to announce the death of a young nurse and mother of Covid-19 😢

Their dedication to work needs to be remembered.

I’m so sorry to hear that, we must never forget the people who are risking their lives every day for all of us. 

[steviewevie]